Men and women aged 55-18 years with ulcerative colitis (mild to moderate). Ulcerative colitis
Conditions
Interventions
Intervention 1: Intervention group1: Receiver of 30 grams of flaxseed per day in the form of fully ground powder-whole flaxseed was ground and sealed in 250 g packages with a 30 g portion and given to
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Age 18 to 55 years Body Mass Index (BMI) 18.5 and above Histopathologically confirmed ulcerative colitis The duration of ulcerative colitis should be at least 3 months. No change in the type and dose of medication used during the last 3 months Patients are in the active stage (mild to moderate) of the disease. Willingness to cooperate in this project
Exclusion criteria
Exclusion criteria: Other intestinal diseases and disorders, autoimmune diseases, cancer, inflammatory and infectious diseases Diabetes or hyperlipidemia (taking drugs that stimulate insulin secretion (such as glibenclamide) or drugs that affect lipid profile (such as statins)) History of gastrointestinal surgery Having other gastrointestinal diseases or gastrointestinal surgery during the study Pregnancy and lactation Use of anti-TNF alpha or immunomodulatory drugs (methotrexate and prednisolone) at or during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic syndrome parameters (fasting glucose, triglycerides, cholesterol, waist circumference and blood pressure). Timepoint: 3 month. Method of measurement: Measurement of blood pressure using mercury sphygmomanometer - Glucose by enzymatic method and using glucose oxidase, total cholesterol by enzymatic method and Cholesterol estrogen and cholesterol oxidase are measured enzymatically using glycerol phosphate oxidase.;Insulin Resistance Index. Timepoint: 3month. Method of measurement: The Homeostasis Model Assessment of IR (HOMA-IR) has proved to be a robust tool for the surrogate assessment of IR.MA-IR= (glucose in mmol/L x insulin in mIU/mL)/22.5.;Serum concentrations of adipokine (resistin and visfatin. Timepoint: 3month. Method of measurement: using ELISA method and special kit instructions.;Serum concentrations of cytokines (interleukin-1 beta and tumor necrosis factor alpha). Timepoint: 3month. Method of measurement: using ELISA method and special kit instructions.;Severity of recurrent colitis. Timepoint: 3month. Method of measurement: Severity of recurrent colitis based on Mayo score questionnaire.;Evaluation of food intake. Timepoint: 3month. Method of measurement: Evaluation of food intake using food frequency questionnaire 168 items. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNava Morshedzadeh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed