Type 2 diabetes mellitus. Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention 1: Intervention group: in this group, each patient will receive a capsule containing lyophilized powder of hydroalcoholic extract of internal septum of walnut (J. regia) three times a day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: Obtain consent from patients Age between 25 and 70 year old HbA1C=7% and less than 9% and FPG = 130-250 mg / dl Take metformin and/or other anti-diabetic agents (in maximum and constant dose for three months) or metformin alone (in maximum and constant dose for three months) Constant diet and physical activity during the study (according to a questionnaire translated and validated into Persian) The patient's anti-diabetic medication regimen remained constant during the study No allergies to walnuts
Exclusion criteria
Exclusion criteria: History of walnut allergy Immune system defects Pregnancy and lactation Cardiovascular disease (coronary artery ischemia, EF <45%) Take medications that change blood glucose levels (corticosteroids, tacrolimus, anti-AIDS drugs, antipsychotic drugs) Uncontrolled thyroid disease Acute infection History of diabetic ketoacidosis eGFR<60 ml/min Acute hepatitis (increase in ALT and AST to more than 10 to 20 times normal) cirrhosis Proliferative retinopathy Severe weight loss (at least 10% over 6 months) Consumption of any other medicine and herbal products, including walnuts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreases of hemogllubin A1C (HbA1C)c. Timepoint: 0 and 12 weeks after initiation of the drug. Method of measurement: serum level measurement. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoha Namazi
Tehran University of Medical Sciences
Outcome results
None listed