Efficacy of Colchicine in Treatment of Covid-19

Evaluation of the Efficacy and Safety of Colchicine plus Methylprednisolone Pulse Therapy in Treatment of Covid-19 Patients with ARDS

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201229049872N1

Enrollment

Registered

2021-04-22

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid 19. Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention 1: Control group: Receiving standard treatment for patients who have ARDS due to covid19 disease including Dexamethasone (8mg daily till 10 days), Interferon beta1(250 microgram till 7 da

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with COVID-19 with moderate to severe respiratory failure admitted to ICU wards

Exclusion criteria

Exclusion criteria: Uncontrolled Diabetes Mellitus Active bacterial or viral (viral Hepatitis and HIV) or fungal infection Positive more than 0.5 Procalcitonin or positive bacterial and fungal culture of any specimen of body Sever Electrolyte disturbance History of severe reaction to Steroidal products Active Gastrointestinal bleeding

Design outcomes

Primary

Measure	Time frame
Evaluation of the efficacy of colchicine plus methylprednisolone pulse therapy in treatment of Covid-19 patients with Respiratory distress. Timepoint: During the hospitalization period. Method of measurement: According to measurement of secondary outcome variables.	—

Secondary

Measure	Time frame
Duration of hospitalization in ICU. Timepoint: During the hospitalization period. Method of measurement: According to ICU hospitalization and discharge time.;Duration of being intubated. Timepoint: During the hospitalization period. Method of measurement: Period between intubation and extubation time.;Duration of staying in hospital. Timepoint: During the hospitalization period. Method of measurement: The difference between the time of admission and the time of discharge.;Patient's death. Timepoint: During the hospitalization period. Method of measurement: Based on patient file information.;SOFA score. Timepoint: During the hospitalization period. Method of measurement: Calculation based on defined table.	—

Measure

Time frame

Duration of hospitalization in ICU. Timepoint: During the hospitalization period. Method of measurement: According to ICU hospitalization and discharge time.;Duration of being intubated. Timepoint: During the hospitalization period. Method of measurement: Period between intubation and extubation time.;Duration of staying in hospital. Timepoint: During the hospitalization period. Method of measurement: The difference between the time of admission and the time of discharge.;Patient's death. Timepoint: During the hospitalization period. Method of measurement: Based on patient file information.;SOFA score. Timepoint: During the hospitalization period. Method of measurement: Calculation based on defined table.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbrahim Hazrati

Artesh University of Medical Sciences

dr.hazrati.e@gmail.com+98 21 8609 6350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026