Neonatal mechanical ventilation, Extubation success, Respiratory distress, Nebulized epinephrine.
Conditions
Interventions
Intervention 1: Intervention group Intervention group (case): Extubation candidate neonates who meet the study entry criteria will receive nebulization immediately after extubation. A dose of 0.5 mg p
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 28 Days
Inclusion criteria
Inclusion criteria: Neonates who are candidates for extubation Duration of Intubation less than one week First etubation session Written consent from parents or legal guardians
Exclusion criteria
Exclusion criteria: Cardiac arrhythmias History of hypertension Hyperthyroidism Dilated cardiomyopathy or ischemic heart disease Congenital stenosis or structural airway abnormality Inherited metabolic diseases or neuromuscular disorders Confirmed or suspected sepsis Any stage of necrotizing entrocolitis Receiving systemic or inhaled corticosteroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation success: Need for reintubation at 24, 48, 72 hours, and up to one week after extubation. Timepoint: Extubation success: defined as the need for reintubation at 24, 48, 72 hours, and up to one week after extubation. Method of measurement: Record patient file information. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of need for non-invasive respiratory support. Timepoint: From the time of first extubation to discharge. Method of measurement: Number of days required for non-invasive ventilation.;Mortality from any cause. Timepoint: Incidence of death from admission. Method of measurement: Physical examination.;Bronchopulmonary dysplasia. Timepoint: 36 weeks. Method of measurement: Clinical observation and chest x ray.;Cardiovascular complications (tachycardia, arrhythmia). Timepoint: From patient admission to hospital discharge. Method of measurement: Physical examination and monitoring.;Incidence of Intraventricular hemorrhage. Timepoint: From patient admission to hospital discharge. Method of measurement: Brain Sonography.;Patent ductus arteriosus requires treatment. Timepoint: From patient admission to hospital discharge. Method of measurement: Echocardiography.;Duration of hospitalization. Timepoint: At the time of discharge from the hospital. Method of measurement: Count the number of hospitalization days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsghar Marzban
Zanjan University of Medical Sciences
Outcome results
None listed