Comparative study of the effect of dexamethasone and injectable hydrocortisone in reducing the need for oxygen in preterm infants

Comparative study of the effect of dexamethasone and injectable hydrocortisone in reducing the need for oxygen in preterm infants with high risk of bronchopulmonary dysplasia admitted to the NICU of Ayatollah Mousavi Hospital in Zanjan in 2021-22.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201222049802N3

Enrollment

Registered

2022-01-25

Start date

2021-09-22

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary dysplasia. Bronchopulmonary dysplasia originating in the perinatal period

Interventions

Intervention 1: Intervention group Dexamethasone: Infants of the dexamethasone group will recieve Dexamethasone injection from day 14 of birth (0.2 mg per kg body weight for the first 3 days and 0.1 m

Eligibility

Sex/Gender

All

Age

No minimum to 231 Days

Inclusion criteria

Inclusion criteria: Fetal age less than 33 weeks The risk of bronchopulmonary dysplasia more than 60% according to the NICHD definition Parental consent Having recieved antenatal corticosteroid

Exclusion criteria

Exclusion criteria: Active systemic or pulmonary infection Existence of congenital anomalies and metabolic diseases requiring surgery

Design outcomes

Primary

Measure	Time frame
Oxygen saturation. Timepoint: day 28 of birth. Method of measurement: pulse oximeter.	—

Secondary

Measure	Time frame
Pulse/Respiration rate. Timepoint: day 28 of birth. Method of measurement: Cardiac monitoring device.;Mechanical ventilation time. Timepoint: day 28 of birth. Method of measurement: Direct observation.;CPAP time. Timepoint: day 28 of birth. Method of measurement: Direct observation.;NICU hospitalization time. Timepoint: day 28 of birth. Method of measurement: Direct observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAsghar Marzban

Zanjan University of Medical Sciences

Drmarzban@zums.ac.ir+98 24 3342 0651

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026