The effect of antibiotic therapy on oral health-related quality of life in patients

Comparison of the effectiveness of complementary antibiotic and standard treatment on oral health-related quality of life in patients with chronic periodontitis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201221049786N1

Enrollment

Registered

2021-02-13

Start date

2021-01-31

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: prescription of Amoxicillin 500 mg and Metronidazole 250 mg (Daroopakhsh Co. made in Iran) every 8 hour for 10 days. Intervention 2: Control group: Placebo similar

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Adult healthy patients over 18 years with moderate to severe generalized chronic periodontitis Bearing at least 16 teeth in oral cavity

Exclusion criteria

Exclusion criteria: Having any other periodontal treatments during the past 6 months History of allergy to Lidocaine, Amoxicillin and Metronidazole Having Corticosteroid or Antibiotic therapy Consuming hormonal drugs and Contraceptives Pregnancy in women based on self-expression

Design outcomes

Primary

Measure	Time frame
Oral health related quality of life. Timepoint: Before surgical procedure, 30 and 90 days after antibiotic therapy. Method of measurement: Oral health impact profile(OHIP-14) and Oral impact on daily performance (OIDP) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJaber Yaghini

Esfahan University of Medical Sciences

j_yaghini@dnt.mui.ac.ir+98 31 3792 5570

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026