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Ketamine versus midazolam as an adjuvant to peribulbar block using single inferonasal injection in patients undergoing vitreoretinal surgery: A randomized controlled trial

Ketamine versus midazolam as an adjuvant to peribulbar block using single inferonasal injection in patients undergoing vitreoretinal surgery: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201220049777N2
Enrollment
93
Registered
2021-07-07
Start date
2021-07-15
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peribulbar block in adult patients undergoing vitreoretinal surgeries..

Interventions

Intervention 1: Control group (Group C) received peribulbar anesthesia with a local anesthetic mixture composed of 4 ml of lidocaine 2%, 75 units of hyaluronidase, and 4 ml of bupivacaine 0.5% to whic

Sponsors

Research Institute of Ophthalmology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients undergoing vitreoretinal surgeries with axial length 20-29 mm Adults (male or female) aged from 30 to 65 years old American Society of Anesthesiologists (ASA) physical status I or II

Exclusion criteria

Exclusion criteria: Uncooperative patients Patients who can’t lie flat for the duration of the procedure as those with skeletal problems or orthopneic patients Patients with coagulopathy or using anticoagulant drugs

Design outcomes

Primary

MeasureTime frame
The onset of globe akinesia. Timepoint: At 1, 3, 5 minutes after the block. Method of measurement: The 3-point scale.;The duration of analgesia. Timepoint: Time from the block till first analgesia required. Method of measurement: The 10-point Visual Analog Scale.

Secondary

MeasureTime frame
The duration of motor block. Timepoint: At 1, 2, 3, 4, and 5 h postoperative. Method of measurement: Clinical assessment of regaining full movement.;The onset of lid akinesia. Timepoint: At 1, 2, and 3 min after the block. Method of measurement: The 3-point scale.;The onset of corneal anesthesia. Timepoint: At 15 seconds intervals for one minute after the block. Method of measurement: Clinical assessment using a cotton pad.;The vital data (blood pressure, oxygen saturation, and pulse rate). Timepoint: Before giving the block (baseline) and then every 5 minutes after the block. Method of measurement: Clinical assessment.

Countries

Egypt

Contacts

Public ContactDr. Noha Osama

Research Institute of Ophthalmology

noha.a.osama22@gmail.com+20 2 35718304

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026