Severe traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: 22 patients in the group receiving curcumin-piperine supplement during the first 12 hours after brain trauma will receive curcumin-piperine tablets at a dose of 500
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 70 years Less than 12 hours have passed since the brain trauma. The patient has been diagnosed with severe non-penetrating traumatic brain injury. The patient's GCS at the time of visit should be equal to or less than 8. Sign the informed consent form
Exclusion criteria
Exclusion criteria: The impossibility of using nasogastric tube feeding Patients with severe trauma are candidates for craniotomy surgery Pregnancy or breastfeeding History of allergy to turmeric or curcumin product Concomitant receipt of any drug or supplement with an antioxidant or anti-inflammatory effect or an approved immune system regulator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein (CRP). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Laboratory tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale (GCS). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Clinical test.;Neutrophil-lymphocyte ratio (NLR). Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Laboratory test.;Sequential Organ Failure Assessment (SOFA) Score. Timepoint: once at study entry and again after receiving the last dose of curcumin-piperine. Method of measurement: Clinical test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHesamoddin Hosseinjani
Mashhad University of Medical Sciences
Outcome results
None listed