Skip to content

Comparison effect of Metformin and combination of acid folic and myo-inositol" in poly cystic ovary syndrome"

Comparison of the effect of metformin and the combination of acid folic and myo-inositol in infertility patients with poly cystic ovary syndrom (PCOS) who undergoing IVF for the test time.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201219049758N1
Enrollment
140
Registered
2021-01-02
Start date
2018-08-23
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Polycystic ovary syndrome.

Interventions

Intervention 1: Intervention group: Received combination of 2000 mg and 200 micro gr Folic acid twice a day. Intervention 2: Control group: Received 500 mg three time a day.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: First IVF No histoty of ovarian manipulation Lack of male infertility factor Patency of fallupian tubes No history of smoking

Exclusion criteria

Exclusion criteria: History of IVF histoty of ovarian manipulation male infertility factor No patency of fallupian tubes history of smoking

Design outcomes

Primary

MeasureTime frame
Improving fertility in patients with polycystic ovary syndrome. Timepoint: Before starting the drug from three months before the start of the IVF cycle until the puncture and then before the puncture then comparison of two drug in fertilization rate. Method of measurement: HCG, Ultrasound.

Secondary

MeasureTime frame
Body Mass Index, Fertilization rate, Abortion rate, EP rate, OHSS rate, Ovum count, Ovum quality, Embryo count, , Embryo quality, Follicle count,Follicle size. Timepoint: Patients took the drug three months before the start of the IVF cycle until the puncture, Body Mass Index was measured before and after the drug was completed. Method of measurement: Body Mass Index: weight(kg) on height(cm2), Fertility: HCG and ultrasound, Abortion: HCG and ultrasound, EP: HCG and ultrasound, OHSS: ultrasound, Follicle size: ultrasound, Follicle count: ultrasound, ovum count: microscopic and embryologist, ovum quality: microscopic and embryologist, Embryo count: microscopic and embryologist, Embryo quality: microscopic and embryologist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFereshteh rastegar

Tehran University of Medical Sciences

rastegar.freshteh@gmail.com+98 21 4403 4589

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026