The effect of Nasturtium officinale extract on biomarkers in asthma patients

The effect of hydroalcoholic extract of Nasturtium officinale on oxidative stress and inflammatory markers in asthma patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201215049726N1

Enrollment

Registered

2021-01-01

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma. Asthma

Interventions

Intervention 1: Intervention group: Nasturtium officinale extract (NOE) capsules 500 mg twice daily for 4 weeks used as a supplementary treatment. Intervention 2: Control group: capsule of 500 mg of f

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Both sexes age 18-65 years asthma diagnosis based on the Global Initiative for Asthma (GINA) asthma symptoms not fully controlled based on ACT (Asthma Control Test) score from 5 to24 no severe asthma exacerbation in the last four weeks Complete conscious satisfaction

Exclusion criteria

Exclusion criteria: smoking history pregnant women taking any preparation containing NOE

Design outcomes

Primary

Measure	Time frame
ACT score. Timepoint: 0-28 days. Method of measurement: Asthma Control Test questionnaire.	—

Secondary

Measure	Time frame
Protein carbonyl. Timepoint: 0-28. Method of measurement: Spectrophotometry.;Total thiol content. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Protein sulfhydryl. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;The ferric reducing antioxidant power. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Glutathione peroxidase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Superoxide dismutase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Catalase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Protein carbonyl. Timepoint: 0-28. Method of measurement: Spectrophotometry.;Total thiol content. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Protein sulfhydryl. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;The ferric reducing antioxidant power. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Glutathione peroxidase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Superoxide dismutase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.;Catalase enzyme. Timepoint: 0-28 days. Method of measurement: Spectrophotometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Doustimotlagh

Yasouj University of Medical Sciences

amirhosseindoustimotlagh@gmail.com+98 74 3334 6070

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026