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Comparison of preventive effects of Ketamine ,fentanyl and paracetamol on Hemodynamic parameters and acute postoperative pain after deep vitrectomy

Comparison of preventive effects of Ketamine ,fentanyl and paracetamol on Hemodynamic parameters and acute postoperative pain after deep vitrectomy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201213049697N1
Enrollment
80
Registered
2021-09-07
Start date
2020-12-16
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Most cases of vitrectomy are performed due to retinal detachment for any reason, including diabetes, trauma, etc..

Interventions

Intervention 1: Intervention group: Ketamine (Group K) 0.5mg / kg will be opened by intravenous infusion within 15 minutes after the volume of the above drugs is increased to 100 cc by sterile normal

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: all patient candidate for deep vitrectomy surgery

Exclusion criteria

Exclusion criteria: each surgery that long more than 3 or less than 1 hour pregnancy addiction to cigarette ,opium and alcohol Inability to speak non iranian nationality more than 100 kg weight choronic pain that last more than 6 month uncontroled systemic diseases such as liver or kidney disease allergy or anaphylaxy to NSAID ,opium and drug that we use in study psychosis ,obvious anxiety before surgery and History of taking anti-anxiety medication

Design outcomes

Primary

MeasureTime frame
Hemodynamic changes (blood pressure, respiration rate, heart rate, blood oxygen saturation). Timepoint: Before the operation, during the operation (at intervals of 15 minutes, 30 minutes, one hour, two hours), after the operation (at intervals of 15 minutes, 30 minutes, one hour, two hours, 4 hours, 16 hours , 24 hours ). Method of measurement: Mercury sphygmomanometer, clock, pulse oximeter.;Acute pain after surgery. Timepoint: Before the operation, during the operation (at intervals of 15 minutes, 30 minutes, one hour, two hours), after the operation (at intervals of 15 minutes, 30 minutes, one hour, two hours, 4 hours, 16 hours , 24 hours ). Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDarioush Moradi Farsani

Esfahan University of Medical Sciences

drdmoradi@gmail.com+98 31 3668 8138

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026