Thalassemia. ?????????? ?????
Conditions
Interventions
Intervention 1: Intervention: Melatonin tablet 3 mg twice at night for 45 days. Intervention 2: Control group: Placebo tablet (twice at night) for 45 days.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Beta thalassemia major Cases who are 18 years old or more Treatment with standard iron chelators at least for two years An unchanged treatment for 3 previous months before the beginning of the study Serum ferritin level higher than 1000 ng/dL Sleep quality index (PSQI)<5
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimating stress oxidative indexes as GSH,CAT,SOD and MDA. Timepoint: before treatment, at the end of Phase1 and at the end of the study. Method of measurement: Tests for oxidative stress with Spectrophotometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of quality of sleep. Timepoint: Before treatment, at the end of Phase1 and at the end of study. Method of measurement: PSQI- Pittsburgh Sleep Quality Index questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmirhossein Sarkhosh
Mazandaran University of Medical Sciences
Outcome results
None listed