Comparison of different doses of ketamine and propofol for changing the dressing in burn patients

Comparison of different doses of ketamine and propofol for sedation and analgesia for changing the dressing in burn patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201210049672N2

Enrollment

120

Registered

2022-03-19

Start date

2022-02-20

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Second- and third-degree burns. Encounter for change or removal of nonsurgical wound dressing

Interventions

Intervention 1: Intervention group: First the patient will receive 1-2 mg intravenous ketamin (MFR:Sterop Co., Belgium) for induction (Each ampule contains 500 mg ketamin/10 ml

therefore, each ml contains 50 mg ketamine, which will be diluted with 4 ml distilled water). During the procedure, whenever the patient's pain score is >3 based on his/her facial expression, 1-3 ml p

therefore, each ml contains 50 mg ketamine, which will be diluted with 4 ml distilled water). Then, equal proportions of ketamine and propofol 1% (each ampule contains 200 mg propofol 1%/20 ml) will b

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 15-65 years Second- and third-degree burns Burn area of 10-70% Daily dressing change before skin graft in the operating room with American Society of Anesthesiologists (ASA) class 1-3 Ability to speak and perceive the Persian language

Exclusion criteria

Exclusion criteria: Drug addiction Respiratory and cardiac diseases Renal disorders Hypersensitivity to analgesic drugs, ketamine, and propofol History of psychiatric disorders History of seizure American Society of Anesthesiologists (ASA) class >3

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: At the end of the procedure. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Sedation. Timepoint: At the end of the procedure. Method of measurement: Ramsay Sedation Scale.;Patient satisfaction. Timepoint: At the end of the procedure. Method of measurement: Poor/moderate/good/excellent.;Surgeon satisfaction. Timepoint: At the end of the procedure. Method of measurement: Poor/moderate/good/excellent.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBibimona Razavi

Bandare-abbas University of Medical Sciences

bibimonarazavi.hums@gmail.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026