Effect of fentanyl with and without topical lidocaine on hemodynamic responses to tracheal intubation

Comparison of intravenous fentanyl with and without topical lidocaine on hemodynamic responses to tracheal intubation; a double-blinded clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201207049639N3

Enrollment

100

Registered

2021-01-06

Start date

2019-06-26

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic response to endotracheal intubation.

Interventions

Intervention 1: Intervention group: The first group received 2µg / kg intravenous fentanyl (Caspian product) and 10 puffs of lidocaine spray 10% (equivalent to 100 mg) (Iran Daru product) about one mi

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age over 20 years and under 60 years American Society of Anesthesiologists (ASA) I and II patients who are candidates for elective surgery under general anesthesia and endotracheal intubation with cuffed tube

Exclusion criteria

Exclusion criteria: Morbid obesity (BMI above 40) History of any disease or abnormality that adversely affects anesthesia and surgery History of any drug use that adversely affects anesthesia and surgery

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Pulsoximeter.;Systolic blood pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.;Diastolic blood pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.;Mean atrial pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.	—

Measure

Time frame

Heart rate. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Pulsoximeter.;Systolic blood pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.;Diastolic blood pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.;Mean atrial pressure. Timepoint: Before intubation, immediately after intubation, 1, 3 and 5 minutes after intubation. Method of measurement: Cardiovascular monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hadi Hooshyar

Oroumia University of Medical Sciences

hooshyar.h@umsu.ac.ir+98 44 3198 8293

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026