Diabetes Mellitus Type 1. Type 1 diabetes mellitus without complications
Conditions
Interventions
Intervention 1: Control group: patients who were under multiple daily insulin injection. dosage is based on patients weight. Basal insulin: Lantus insulin by Sanofi 100U/ml, Bolus Insulin: Novorapid i
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 20 Years
Inclusion criteria
Inclusion criteria: Age from 10 to 20 years old Duration of Type 1DM more than one year Insulin dosage more than one unit/ kg /day Multiple daily insulin injections from at least 1 year ago HbA1c more than 8% in the past 6 months
Exclusion criteria
Exclusion criteria: Nephropathy Proliferative retinopathy Diabetic ketoacidosis more than twice a year Recurrent severe hypoglycemia Current insulin therapy by conventional method (NPH plus Reg) Renal or hepatic dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1C concentration alteration after metformin consumption. Timepoint: Before intervention, 3 months, 6 months, and 9 months after intervention. Method of measurement: Blood test.;Creatinine concentration alteration after metformin consumption. Timepoint: Before intervention, 3 months, 6 months, and 9 months after intervention. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHedyeh Saneifard
Shahid Beheshti University of Medical Sciences
Outcome results
None listed