Comparison of the effect of tranexamic acid and phenylephrine on bleeding rate in rhinoplasty

Comparative study of local effect of tranexamic acid and phenylephrine on bleeding rate in rhinoplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201205049602N1

Enrollment

Registered

2021-04-24

Start date

2020-12-06

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty. Acquired deformity of nose

Interventions

Intervention 1: Intervention group: In the first group, 1 cc of phenylephrine (Phenylephrine Hcl, Nasal Drop, 0.5%) is drawn with a syringe and poured on the mesh and packed for five minutes immediate

Eligibility

Sex/Gender

All

Age

20 Years to 30 Years

Inclusion criteria

Inclusion criteria: Candidate patients for rhinoplasty willingness to participate in the intervention full consciousness age 20-30 years

Exclusion criteria

Exclusion criteria: Sensitivity known to tranexamic acid and phenylephrine Tachycardia and high blood pressure140/90 History of coagulation disorder, warfarin use Sensitivity known to tranexamic acid high blood pressure140/90 History of warfarin use

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Calculation of the amount of blood in the suction and the surgeon's satisfaction with the surgical field.;Tachycardia. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Using patient vital signs monitoring.;Blood pressure. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Using patient vital signs monitoring.	—

Measure

Time frame

Bleeding. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Calculation of the amount of blood in the suction and the surgeon's satisfaction with the surgical field.;Tachycardia. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Using patient vital signs monitoring.;Blood pressure. Timepoint: Before the intervention, 5, 15 and 30 minutes after the intervention. Method of measurement: Using patient vital signs monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNegar shahkarmi

Mazandaran University of Medical Sciences

negar.shahkarami@yahoo.com+98 71 3222 0639

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 6, 2026