Evaluation of the effect of promethazine prescription on improving endoscopy

Evaluation of the promethazine prescription effect on sedation, nausea reduction and quality of the upper Esophageal gastro Endoscopy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201204049599N4

Enrollment

Registered

2021-05-15

Start date

2021-05-05

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper gastrointestinal endoscopy.

Interventions

Intervention 1: Intervention group: In the intervention group, 30 cc of promethazine syrup in 100 cc of drinking water made by Emad Darman Pars Pharmaceutical Company (1mg /1cc ) will be given to the

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age 18 to 40 years Systolic blood pressure greater than 90 and less than 130 mm Hg Peripheral blood oxygen saturation with pulse oximetry is more than 95% Respiratory rate between 12 and 18 times per minute Do not take certain medications for a long time other than antacids.

Exclusion criteria

Exclusion criteria: pregnancy Presence of diabetes, hypertension, thyroid disease, heart disease, liver disease such as cirrhosis and hepatitis, chronic or acute lung disease, Rheumatologic disease, neurological disease

Design outcomes

Primary

Measure	Time frame
Total procedure time. Timepoint: During endoscopy. Method of measurement: Minute / Stopwatch.;Patient cooperation. Timepoint: During endoscopy. Method of measurement: Less than 5 retching, excellent / 6-10 times retching, good / 11-15 times retching, moderate / more than 16 retching, bad.;Endoscopist Satisfaction. Timepoint: During endoscopy. Method of measurement: Endoscopist Statement: Easy Completion / Relatively Easy Completion / Difficult Completion / Incomplete.;Patient satisfaction. Timepoint: During endoscopy. Method of measurement: Patient statement: very good / good / average / unpleasant.;Recovery time. Timepoint: After endoscopy until discharge. Method of measurement: Minute / Stopwatch.;Complications. Timepoint: From the time of drug administration until 24 hours later. Method of measurement: Through examination and self-declaration of the patient: yes / no.;Patient Anxiety. Timepoint: During endoscopy. Method of measurement: Patient statement in response to the anxiety level question: very high / high / medium / low / very low / not at all.;Patient level of consciousness. Timepoint: During endoscopy. Method of measurement: Assess the patient's level of consciousness based on the Glasgow Coma Scale.	—

Measure

Time frame

Total procedure time. Timepoint: During endoscopy. Method of measurement: Minute / Stopwatch.;Patient cooperation. Timepoint: During endoscopy. Method of measurement: Less than 5 retching, excellent / 6-10 times retching, good / 11-15 times retching, moderate / more than 16 retching, bad.;Endoscopist Satisfaction. Timepoint: During endoscopy. Method of measurement: Endoscopist Statement: Easy Completion / Relatively Easy Completion / Difficult Completion / Incomplete.;Patient satisfaction. Timepoint: During endoscopy. Method of measurement: Patient statement: very good / good / average / unpleasant.;Recovery time. Timepoint: After endoscopy until discharge. Method of measurement: Minute / Stopwatch.;Complications. Timepoint: From the time of drug administration until 24 hours later. Method of measurement: Through examination and self-declaration of the patient: yes / no.;Patient Anxiety. Timepoint: During endoscopy. Method of measurement: Patient statement in response to the anxiety level question: very high / high / medium / low / very low / not at all.;Patient level of consciousness. Timepoint: During endoscopy. Method of measurement: Assess the patient's level of consciousness based on the Glasgow Coma Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Pashaee

Oroumia University of Medical Sciences

pashaee.m@umsu.ac.ir+98 44 3198 8001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026