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Effect of Naproxen in the treatment of cellulitis

Comparison of the efficacy of Cefazolin and Naproxen with Cefazolin only in the treatment of cellulitis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201204049598N1
Enrollment
60
Registered
2021-09-08
Start date
2020-03-19
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cellulitis. Cellulitis and acute lymphangitis

Interventions

Intervention 1: Intervention group: The intervention group received Cefazolin (1.5-1 g intravenously every 8 hours) and Naproxen (500 mg orally every 12 hours) until the end of hospitalization. The dr

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hospitalized patients with a diagnosis of cellulitis Age over 18 years Willingness to participate in this clinical trial

Exclusion criteria

Exclusion criteria: Allergy to Penicillin, Cefazolin or Naproxen Pregnant women Immunodeficiency Patients with mucocutaneous diseases Patients with kidney diseases Patients with vascular catheters Patients suspected of having septic arthritis or osteomyelitis Patients with infected diabetic foot ulcers Bite or the presence of a foreign body in the wound Perianal cellulitis Injecting substance abuse Hospitalization during the last three months Chronic hemodialysis patients

Design outcomes

Primary

MeasureTime frame
Erythema. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Warmth. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Tenderness. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Body temperature. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Using a mercury thermometer.;Reduce exudate secretion from the wound. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Hospitalization duration. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Medical record.

Secondary

MeasureTime frame
Epigastric pain. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Diarreha. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Itching. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.;Skin rash. Timepoint: Before the intervention, 2, 3, and 5 to 7 days after the start of the intervention. Method of measurement: Trained doctor report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSadaf Saket

Shahid Beheshti University of Medical Sciences

dasdd272@yahoo.com+98 21 2231 3681

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026