Evaluate the effectiveness of ozone therapy on recuperation of patient suffering from Medication-related osteonecrosis of the jaw

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201201049555N1

Enrollment

Registered

2020-12-06

Start date

2019-11-13

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteonecrosis. Osteonecrosis due to drugs

Interventions

Intervention 1: Intervention group: Ozone therapy with surgery for patients with drug-induced osteonecrosis of the jaw. Intervention 2: Control group: Traditional debridement and surgery for patients

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Exposed bone or bone that can be probed through an intraoral or extraoral fistula that remains in the maxillofacial region for more than 8 weeks. No history of radiotherapy Possibility of frequent visits for ozone therapy sessions

Exclusion criteria

Exclusion criteria: Existence of pathological fractures while entering the study Pregnant patients Poor prognosis of cancer (with five-year SR less than 10%) Incidence of pathological fractures in the jaw in the affected area Perform radiotherapy during the treatment process

Design outcomes

Primary

Measure	Time frame
Tenderness pain. Timepoint: After intervention. Method of measurement: Examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnaz Dehabadi

Mashhad University of Medical Sciences

eshghpourm@gmail.com+98 51 3841 3492

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026