Effectiveness of Oral Acyclovir in Treatment of Infectious Mononucleosis in Children

Effectiveness of Oral Acyclovir in Treatment of Infectious Mononucleosis in Children, Iran, Gorgan, Taleghani Hospital ,2021; A Double Blind Placebo Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201201049554N1

Enrollment

Registered

2021-02-21

Start date

2021-03-05

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious Mononucleosis. Cytomegaloviral mononucleosis, without complications

Interventions

Intervention 1: Intervention group: Acyclovir 80 mg / kg / 24hr recipients in 4 divided doses for 5 days (acyclovir tablets made by Amin Pharma, Iran). Intervention 2: Control group: Placebo group (s

Eligibility

Sex/Gender

All

Age

1 Years to 16 Years

Inclusion criteria

Inclusion criteria: Children (1 to 16 years old) who have symptoms of the disease including sore throat, lymphadenopathy and fatigue Symptoms begin within the last 3 days fever 38 c

Exclusion criteria

Exclusion criteria: No need for hospitalization Underlying diseases such as diabetes and asthma Antiviral and steroid treatment for the past 2 weeks serum creatinine higher than 1.6

Design outcomes

Primary

Measure	Time frame
Reduce the hospitalization duration. Timepoint: The patient's general condition and the presence of respiratory distress will be assessed daily after starting treatment. Method of measurement: Medical assessment and physical examination.;Reduce severity of disease. Timepoint: The presence of fever, exudative sore throat, respiratory distress, stridor is evaluated daily after starting treatment. Method of measurement: Medical assessment and physical examination.	—

Measure

Time frame

Reduce the hospitalization duration. Timepoint: The patient's general condition and the presence of respiratory distress will be assessed daily after starting treatment. Method of measurement: Medical assessment and physical examination.;Reduce severity of disease. Timepoint: The presence of fever, exudative sore throat, respiratory distress, stridor is evaluated daily after starting treatment. Method of measurement: Medical assessment and physical examination.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdolmotaleb Mazidi

Gorgan University of Medical Sciences

drmazidimd@gmail.com+98 17 3220 2565

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026