?Behavioral and psychological symptoms of dementia (BPSD). Unspecified dementia with behavioral disturbance
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group receive Pregabalin with the initial dose 50mg per day, the dose increases every week to the maximum of 150 mg twice a day for 12 weeks. Both
Sponsors
Tehran University of Medical Sciences Deputy of Research and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with dementia of the following types: Alzheimer's, vascular dementia or mixed vascular dementia, based on DSM V criteria Patients with moderate to severe dementia based on the result of diagnostic tools such as FAST or MoCA
Exclusion criteria
Exclusion criteria: Other types of dementia such as Lewy body or frontotemporal dementia History of major psychological disorders History of drug abuse History of epilepsy or other neurological disorders such as Multiple Sclerosis or head concussion which may exacerbate behavioral symptoms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sum of score for Behavioural Pathology in Alzheimer's Disease questionnaire. Timepoint: Before Taking pregabalin, and 4,8,12 weeks after taking pregabalin. Method of measurement: Behavioural Pathology in Alzheimer's Disease questionnaire.;Sum of score for Neuropsychiatric Inventory questionnaire. Timepoint: Before Taking pregabalin, and 4,8,12 weeks after taking pregabalin. Method of measurement: Neuropsychiatric Inventory (NPI) questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sum of score of dementia quality of life questionnaire. Timepoint: Before taking Pregabalin and on the weeks of 4,8,12 after taking pregabalin. Method of measurement: dementia quality of life (qol) questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeyla maleki
Tehran University of Medical Sciences
Outcome results
None listed