Evaluation of the effect of selenium on patients with thyroid cancer treated with radioactive iodine

Evaluation of the effect of selenium supplementation on sonographic findings of salivary glands and inflammatory factors and oxidative stress in patients with thyroid cancer treated with radioactive iodine

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201129049534N6

Enrollment

Registered

2021-09-16

Start date

2021-10-06

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid cancer. Neoplasm of uncertain behavior of thyroid gland

Interventions

Intervention 1: Intervention group: Patients receiving a selenium capsule containing 200 micrograms of selenium per day for 10 days (3 days before treatment with radioactive iodine to 6 days after tre

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Ages 20 to 65 Diagnosis of thyroid cancer by imaging, such as ultrasound, computed tomography, magnetic resonance imaging, and positron tomography (PET) scan

Exclusion criteria

Exclusion criteria: History of sialadenitis (inflammation of the salivary glands) Sjogren's history History of collagen vascular disease involving the salivary glands. History of any salivary gland surgery Follow a special diet in the last 3 months Pregnancy and lactation Patient dissatisfaction to participate in the study Taking dietary supplements in the last 3 months Suffering from certain diseases such as diseases caused by congenital diseases, immune system defects, etc.

Design outcomes

Primary

Measure	Time frame
Clinical status of salivary glands. Timepoint: At baseline and end of the study. Method of measurement: Ultrasound of major salivary glands (including examination of echogenicity, size, margin and contour).;C reactive Protein (CRP). Timepoint: At baseline and end of the study. Method of measurement: ELISA test.;Total oxidative stress. Timepoint: At baseline and end of the study. Method of measurement: Commercial diagnostic kit.;Total antioxidant capacity. Timepoint: At baseline and end of the study. Method of measurement: Commercial diagnostic kit.;Sense of taste. Timepoint: At baseline and end of the study. Method of measurement: Questionnaire designed by the researcher.;The rate of salivary gland secretion. Timepoint: At baseline and end of the study. Method of measurement: Questionnaire designed by the researcher.	—

Measure

Time frame

Clinical status of salivary glands. Timepoint: At baseline and end of the study. Method of measurement: Ultrasound of major salivary glands (including examination of echogenicity, size, margin and contour).;C reactive Protein (CRP). Timepoint: At baseline and end of the study. Method of measurement: ELISA test.;Total oxidative stress. Timepoint: At baseline and end of the study. Method of measurement: Commercial diagnostic kit.;Total antioxidant capacity. Timepoint: At baseline and end of the study. Method of measurement: Commercial diagnostic kit.;Sense of taste. Timepoint: At baseline and end of the study. Method of measurement: Questionnaire designed by the researcher.;The rate of salivary gland secretion. Timepoint: At baseline and end of the study. Method of measurement: Questionnaire designed by the researcher.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Bagherniya

Esfahan University of Medical Sciences

bagherniya@nutr.mui.ac.ir+98 31 3972 3138

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 8, 2026