The effect of aerobic training at home and vitamin D supplementation in MS During Covid-19 quarantine

The effect of an 8-week aerobic training at home and vitamin D supplementation on serum values of Brain-derived neurotrophic factor (BDNF), Nerve growth factor (NGF), fatigue level and quality of life in patients with Multiple Sclerosis During Covid-19 quarantine

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201129049525N1

Enrollment

Registered

2021-05-16

Start date

2021-05-20

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group 1: Aerobic training + vitamin D supplementation group: The aerobic training + vitamin D supplementation Intervention will be consists of 25-40 minutes of aerobic ex

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: All patients with Multiple sclerosis (MS) with at least 2 years of history Lack of regular exercise Do not take immunosuppressive drug No smoking Expanded Disability Status Scale (3-5)

Exclusion criteria

Exclusion criteria: Heart disease High blood pressure Orthopedic disorders Use of other drugs in addition to MS drugs

Design outcomes

Primary

Measure	Time frame
Vitamin D. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Brain-derived neurotrophic factor. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Nerve growth factor. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;IL-10. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;TNF-Alpha. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Fatigue. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By questionnaire.;Quality of life. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By questionnaire.	—

Measure

Time frame

Vitamin D. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Brain-derived neurotrophic factor. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Nerve growth factor. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;IL-10. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;TNF-Alpha. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By Blood sampling.;Fatigue. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By questionnaire.;Quality of life. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRastegar Hoseini

Razi University

R.hoseini@razi.ac.ir+98 83 3427 7605

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 6, 2026