Prevention of pancreatitis by epinephrine spray after endoscopic retrograde cholangiopancreatography

Assessment of epinephrine spray versus placebo for prevention from acute pancreatitis following endoscopic retrograde colangiopancreatography (ERCP)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201128049521N1

Enrollment

140

Registered

2020-12-15

Start date

2018-03-21

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pancreatitis. Acute pancreatitis

Interventions

Intervention 1: Intervention group: By the end of the procedure, 20 ml of epinephrine 0.02% (Darupakhsh

Iran) was sprayed on the papilla for a minute. Intervention 2: Control group: By the end of the procedure, 20 ml normal saline was sprayed on the papilla for a minute.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Over 18 years old of age Indication for ERCP due to any etiology Willingness for participation in the study

Exclusion criteria

Exclusion criteria: Any contraindication for epinephrine administration (hyperthyroidism, cardiac arrhythmia) Uncontrolled cardiac ischemic disease Previous history of acute and chronic pancreatitis Previous history of pancreatic duct manipulation

Design outcomes

Primary

Measure	Time frame
Increase in blood amylase. Timepoint: At baseline and within 24 hours after ERCP. Method of measurement: Blood sample.;Increase in blood lipase. Timepoint: At baseline and within 24 hours after ERCP. Method of measurement: Blood sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLaleh Raeisi Bidakani

Esfahan University of Medical Sciences

raesibidakanilaleh@gmail.com+98 31 3444 7707

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026