The effect of exercise and Mulberry leaf extract on some cardiovascular inflammatory markers in the elderly with type 2 diabetes

The effect of combined exercises and the consumption of Mulberry leaf extract on the serum levels of alpha and beta salucin and some related inflammatory or cardiovascular markers in elderly men with type 2 diabetes

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201128049510N1

Enrollment

Registered

2022-12-07

Start date

2022-11-17

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: Intervention group 1: Combined exercise (aerobic and resistance): Aerobic exercises will be performed for 10 to 30 minutes with an intensity between 50 and 70% of t

Eligibility

Sex/Gender

Male

Age

60 Years to 70 Years

Inclusion criteria

Inclusion criteria: Having type 2 diabetes between one and 10 years Not taking more than one type of oral anti-diabetic pill at night Having a basic level of glycosylated hemoglobin between 6.6 and 9.9% Having a fasting blood glucose of 160 to 250 mg/dL Ability to do sports Not participating in a regular exercise program for at least 6 months before the start of the study

Exclusion criteria

Exclusion criteria: Taking more than one type of oral anti-diabetic pill at night Smoking having cardiovascular, kidney and eye diseases, complications of diabetes (neuropathy, nephropathy, retinopathy) Treated with insulin

Design outcomes

Primary

Measure	Time frame
Salusin alpha. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Salusin beta. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Lipocalin 2. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Galectin 3. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Interleukin 6. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Interleukin 1 beta. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Insulin. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Glucose. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.	—

Measure

Time frame

Salusin alpha. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Salusin beta. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Lipocalin 2. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Galectin 3. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Interleukin 6. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Interleukin 1 beta. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Insulin. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.;Glucose. Timepoint: 24 hours before and 48 hours after training. Method of measurement: Blood sampling and using a laboratory kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoghayyeh Afroundeh

University of Mohaghegh Ardabili

afroundeh@uma.ac.ir+98 45 3150 5193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026