Knee osteoarthritis.
Conditions
Interventions
Intervention 1: Intervention group: Marhame-Mafasel ointment contains Arnebia euchoma as the main plant, peppermint, and chamomile essential oil. Arnebia euchroma is a perennial herbaceous plant in th
Sponsors
Shahed University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patient satisfaction and signing of informed consent form Patients with moderate knee osteoarthritis (individuals who classified in grade 3 or moderate included moderate joint space narrowing according to Kellgren-Lawrence classification ) individuals between 40-80 years
Exclusion criteria
Exclusion criteria: Lack of cooperation of patients Patients with mild or severe knee osteoarthritis History of allergy to topical Nonsteroidal anti-inflammatory drugs (NSAIDs) Patients with a history of steroid injection into the knee joint in the past three months Consumption of oral Nonsteroidal anti-inflammatory drugs (NSAIDs) History of asthma or any liver or kidney disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of ESR (Erythrocyte Sedimentation Rate). Timepoint: 1months after and before treatment. Method of measurement: Manual.;Evaluation of CRP (C-Reactive Protein). Timepoint: 1 months after and before treatment. Method of measurement: Quantitative method with diagnostic kit.;Evaluation of Rheumatoid Factor (RF). Timepoint: 1 months after and before treatment. Method of measurement: Quantitative method with diagnostic kit.;Assay of TNF-a (Tumor necrosis factor a). Timepoint: 1 months after and before treatment. Method of measurement: ELISA method.;Assay of Interleukin 6 (IL-6). Timepoint: 1 months after and before treatment. Method of measurement: ELISA method.;Evaluation of WOMAC questionnaire or Western Ontario and McMaster Universities Osteoarthritis Index to measure and determine the severity of the disability. Timepoint: 1 months after and before treatment. Method of measurement: Questionnaire.;Evaluation of visual analog scale (VAS). Timepoint: 1 months after and before treatment. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of World Health Organization Quality of Life-BREF (WHOQOL-BREF). Timepoint: 1 months after and before treatment. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzadeh Mizani
Shahed University
Outcome results
None listed