Rheumatoid arthritis disease. Rheumatoid arthritis, unspecified
Conditions
Interventions
Intervention 1: Melissa officinalis is a perennial herbaceous plant in the mint family (Lamiaceae). Scientific research of this plant shows that it has anti-inflammatory, analgesic, and anti-depressa
Sponsors
Shahed University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patient satisfaction and signing of informed consent form Diagnosis of patients with moderate Rheumatoid Arthritis Using the Criteria of the American College of Rheumatology Patients over 18 years During the period of the disease up to 15 years DAS Score between 3-5
Exclusion criteria
Exclusion criteria: Lack of cooperation of patients History of Heart, kidney, liver and ... diseases Pregnancy Any kind of Immunodeficiency diseases No other autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of Disease Activity Score 28 (DAS 28). Timepoint: 2 months after and before treatment. Method of measurement: DAS Calculator software.;Evaluation of ESR (Erythrocyte Sedimentation Rate. Timepoint: 2 months after and before treatment. Method of measurement: Using Westergren method.;Evaluation of Rheumatoid Factor (RF). Timepoint: 2 months after and before treatment. Method of measurement: Quantitative method with diagnostic kit.;Evaluation of CRP (C-Reactive Protein). Timepoint: 2 months after and before treatment. Method of measurement: Quantitative method with diagnostic kit.;Evaluation of Anti ccp (Cyclic Citrirullinated Peptide). Timepoint: Before treatment. Method of measurement: ELISA method.;Assay of TNF-a (Tumor necrosis factor a). Timepoint: 2 months after and before treatment. Method of measurement: ELISA method.;Assay of Interleukin 17 (IL-17). Timepoint: 2 months after and before treatment. Method of measurement: ELISA method.;?Evaluation of visual analog scale (VAS). Timepoint: 2 months after and before treatment. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of World Health Organization Quality of Life-BREF (WHOQOL-BREF). Timepoint: 2 months after and before treatment. Method of measurement: Questionnaire.;Evaluation of Beck Depression Inventory (BDI-II). Timepoint: 2 months after and before treatment. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzadeh Mizani
Shahed University
Outcome results
None listed