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Comparison the effect of 3 day with 7 day GNRH-antagonist in prevention of ovarian hyperstimulation syndrome(OHSS)

Comparison the effect of 3 days with 7 days GNRH-antagonist in prevention of ovarian hyperstimulation syndrome(OHSS) in women undergoing assisted reproductive technology (ART)

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201126049497N1
Enrollment
40
Registered
2021-11-09
Start date
2021-10-18
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian hyperstimulation syndrome. Hyperstimulation of ovaries

Interventions

Intervention 1: Intervention group: drug(cetrotide) for 3 days. Intervention 2: Intervention group:drug(cetrotide) for 7 days.

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Having informed consent to enter the study. The possibility of useful intervention on individuals. Age between 18 and 40 years. The person is at risk for OHSS syndrome (for example, the number of recovered eggs is more than 15 or serum estradiol more than 3000 pg / ml Any person who does not meet any of the exclusion criteria will be included in the study if satisfied

Exclusion criteria

Exclusion criteria: Dissatisfaction to enter the study Age less than 18 years or more than 40 years Any disease that interferes with the intended intervention. Patient with diabetes / hemophilia or coagulation disorde Patients with pulmonary fibrosis, swelling or inflammation around the heart or lungs, high blood pressure, liver disease, heart valve disease, or allergy to cabergoline or ergot derivatives Use of drugs that affect the development of OHSS syndrome (calcium gluconate / metformin / letrozole / other GNRH-ant antagonists) Pregnancy during the study cycle Contraindications that are considered by a specialist and are not included in the test.

Design outcomes

Primary

MeasureTime frame
Ovarian hyperstimulation syndrome. Timepoint: One week after OPU. Method of measurement: Clinical and laboratory evaluation and sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactvajihe hazari

Birjand University of Medical Sciences

vajihehazari@bums.ac.ir+98 56 3243 6691

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026