Effect of triggering ovulation with HCG alone and dual triggering by HCG plus GnRh agonist on oocytes maturation and clinical pregnancy rate in POSEIDON group 4 in IVF cycles

Examining the effect of triggering ovulation with HCG alone and dual triggering by HCG plus GnRh agonist on oocytes maturation and clinical pregnancy rate in POSEIDON group 4 in IVF cycles

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201121049457N2

Enrollment

170

Registered

2024-03-16

Start date

2024-04-08

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility associated with anovulation. Female infertility associated with anovulation

Interventions

Intervention 1: Intervention group: Triggering ovulation with gonadotropin starts at a dose of 300 to 450 units daily from the second day of antagonist cycles. The daily r-FSH dose is adjusted based o

Eligibility

Sex/Gender

Female

Age

35 Years to No maximum

Inclusion criteria

Inclusion criteria: POSEIDON group 4 Age is equal to or above 35. The AMH is lower than 1.2 ng/ml AFC is lower than 5-7 in both ovaries

Exclusion criteria

Exclusion criteria: Hypothyroidism Ovarian endometriosis Uncorrected uterine abnormalities Untreated hydrosalpinx Hyperprolactinemia Congenital adrenal syndromes Cushing syndrome Diabetes

Design outcomes

Primary

Measure	Time frame
The quality of the egg after oocyte puncture. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: The number of metaphase II eggs.;Pregnancy rate. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: Beta-GCG positivity.;Clinical pregnancy. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: Visualization of a pregnancy sac containing a heartbeat on ultrasound.	—

Measure

Time frame

The quality of the egg after oocyte puncture. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: The number of metaphase II eggs.;Pregnancy rate. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: Beta-GCG positivity.;Clinical pregnancy. Timepoint: 3 to 4 weeks after embryo transfer. Method of measurement: Visualization of a pregnancy sac containing a heartbeat on ultrasound.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMalihe Amirian

Mashhad University of Medical Sciences

Amirianm@mums.ac.ir+98 51 3802 2608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026