The effect of Resistance Training with Creatine Monohydrate Supplementation on Oxidative Stress and Antioxidant Indices

The Effects of 8 Weeks of Resistance Training with Creatine Monohydrate Supplementation on Oxidative Stress and Antioxidant Indices in Older Adults

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201121049453N1

Enrollment

Registered

2021-01-27

Start date

2021-02-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistance training. Activities involving other muscle strengthening exercises

Interventions

Intervention 1: Intervention group 1: 15 participants as a resistance training + creatine monohydrate supplement group received 0.1g•kg/day of creatine (under license from Canada, Gene Star Company an

Eligibility

Sex/Gender

All

Age

55 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 55-70 years old

Exclusion criteria

Exclusion criteria: Back pain History of lumbar surgery Cardiovascular disease Metabolic sickness history Clinical limitations for sports activities

Design outcomes

Primary

Measure	Time frame
Malondialdehyde (MDA). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;Glutathione peroxidase (GPX). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;Total antioxidant capacity (TAC). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;8-hydroxy-2' -deoxyguanosine (8-OHdG). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.	—

Measure

Time frame

Malondialdehyde (MDA). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;Glutathione peroxidase (GPX). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;Total antioxidant capacity (TAC). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.;8-hydroxy-2' -deoxyguanosine (8-OHdG). Timepoint: Before and after 8 weeks resistance training. Method of measurement: By ELISA method.

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Secondary

Measure	Time frame
Muscle strength. Timepoint: Before and after 8 weeks resistance training. Method of measurement: One Repetition maximum.;Blood Creatinine. Timepoint: Before and after 8 weeks resistance training. Method of measurement: Blood sampling.;Quality of Life. Timepoint: Before and after 8 weeks resistance training. Method of measurement: Questionnaire (SF-36) Quality of Life.;Body mass index. Timepoint: Before and after 8 weeks resistance training. Method of measurement: weight(kg)/height(m2).	—

Measure

Time frame

Muscle strength. Timepoint: Before and after 8 weeks resistance training. Method of measurement: One Repetition maximum.;Blood Creatinine. Timepoint: Before and after 8 weeks resistance training. Method of measurement: Blood sampling.;Quality of Life. Timepoint: Before and after 8 weeks resistance training. Method of measurement: Questionnaire (SF-36) Quality of Life.;Body mass index. Timepoint: Before and after 8 weeks resistance training. Method of measurement: weight(kg)/height(m2).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Amiri

University of Kurdistan

ehsan.amiri93@gmail.com+98 87 3366 4600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026