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Comparison of Two Methods of Combined Less Dense Laser and Bevacizumab Treatment of Pre threshold ROP Type 1 Zone 2 (Stair Method)

Comparison of two methods of combined less dense laser and bevacizumab treatment of prethreshold ROP type 1 zone 2 (stair method):a randomized controlled trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201120049450N5
Enrollment
80
Registered
2024-07-23
Start date
2024-06-30
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal disorders. Other retinal disorders

Interventions

Intervention group: Two IVB and laser treatments for ROP will be compared: Group 1 has posterior dense laser (0.5 interval) and anterior less dense (1 interval), while Group 2 has posterior less dens

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Months to No maximum

Inclusion criteria

Inclusion criteria: Type 1 ROP in Zone II will be incorporated in the study

Exclusion criteria

Exclusion criteria: Neonates with ROP criteria who were not in the Type 1 ROP in Zone II group were not included in the study Threshold ROP ROP stage 4–5 Vitreous hemorrhage Neovascularization of iris Aggressive posterior ROP Elevated ridge

Design outcomes

Primary

MeasureTime frame
A study on premature infants compared two combined IVB and laser treatments for Type 1 ROP, evaluating outcomes (Regression of neovascularization and plus disease) and complications (cataract, vitreous hemorrhage and ...). Timepoint: Weekly, biweekly, and bimonthly follow-ups. Method of measurement: Regression time and complications will be evaluated.

Secondary

MeasureTime frame
Refractive errors. Timepoint: 6 months old. Method of measurement: Retinoscopy.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Namvar

Shiraz University of Medical Sciences

namvar_e@sums.ac.ir+98 71 3629 1470

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026