Rheumatoid arthritis. Rheumatoid arthritis with rheumatoid factor
Conditions
Interventions
Intervention 1: Intervention group: 30 grams of low-salt and low-fat probiotic cheese of Pegah Company daily for 12 weeks. Once every three weeks, enough packages of probiotic cheese will be distribu
Sponsors
Tehran University of Medical Sciences
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Subjects with mild to moderate RA diagnosed by a rheumatologist using the ACR (American College of Rheumatology) criteria Women aged 20–60 years Following stable drug therapy At least in the last three months BMI 25–40 kg/m2
Exclusion criteria
Exclusion criteria: Suffered from other inflammatory diseases including pancreatitis, IBD and myocarditis Pregnant or breastfeeding Tobacco or drug use Alcoholic beverages consumption Liver or kidney disorder Gastrointestinal disorders or lactose intolerance Dietary supplements consumption at least one month before the intervention Using antibiotics one month before the intervention Follow a weight loss diet over the past month Consumption of probiotic foods during the last month Acute heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of high-sensitivity C-reactive protein (High-sensitivity C-reactive protein is an acute-phase protein that produced by the liver in response to inflammation). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the start). Method of measurement: Using a special commercial kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of disease assessment. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the intervention). Method of measurement: Das-28 questionnaire.;Assessment of disability related disease. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the intervention). Method of measurement: HAQ-DI ( health assessment questionnaire-disability index).;Serum level of Interleukin 6 (Interleukin 6 is an endogenous chemical which is active in inflammation, and in B cells maturation). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the start). Method of measurement: Using a special commercial kit.;Serum level of Interleukin 10 (Interleukin 10 is an anti-inflammatory cytokine also known as human cytokine synthesis inhibitory factor (CSIF)). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the start). Method of measurement: Using a special commercial kit.;Serum level of Tumor necrosis factor alpha (Tumor necrosis factor alpha is is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the start). Method of measurement: Using a special commercial kit.;Serum level of erythrocyte sedimentation rate ( Erythrocyte sedimentation rate is a type of blood test that measures how quickly erythrocytes settle at the bottom of a test tube that contains a blood sample and indirectly measures the degree of inflammation present in the body). Timepoint: At the beginning of the study (before the intervention) and at the end of the study (84 days after the start). Method of measurement: Using a special commercial | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzaneh Asoudeh
Tehran University of Medical Sciences
Outcome results
None listed