We perform combined exercises that include aerobic and resistance training on subjects who are middle-aged men who have undergone cardiac bypass surgery. We examined its effects on ABCB4 gene expression, APOA levels and reverse cholesterol transfer.

The effect of a combined training course on lipid profile; APOA levels and expression of ABCB4 white blood cell gene in middle-aged men after cardiovascular bypass surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201117049424N1

Enrollment

Registered

2021-06-09

Start date

2017-08-24

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Cardiovascular disease. Condition 2: Coronary artery diseaseI70-I79. Condition 3: Circulatory system diseaseI95-I99. I60-I69????????? ???? ?????? I70-I79?????????? ?????? ???????? ?????? ????? ???? ???I95-I99

Interventions

Intervention 1: "Intervention group": 8 weeks of cardiac rehabilitation (aerobic training and resistance training) including 3 sessions per week with an intensity of 50-80% of the reserve heart rate o

2,Walking on a treadmill for 20 to 30 minutes ",

" Intervention group: 1:

3, pedaling on a stationary bike 12-10 minutes "

: Intervention group: 1:

4, using manual ergometer is 10 minutes and resistance training includes:" Intervention group 1:5

There are three movements for the upper limb and two movements for the lower limb. Intervention 2: Control group: Control group: No exercise was given to the control group.

Eligibility

Sex/Gender

Male

Age

50 Years to 60 Years

Inclusion criteria

Inclusion criteria: Systolic blood pressure greater than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Cognitive, visual and auditory health Use walking aids such as canes and walkers. eir operating capacity should not be less than five meters. Hermet expresses consumption of 3.5 ml of oxygen per kilogram of body weight per minute, which was estimated based on the modified Bruce test (Fallahi Vagini 2012). Use of neuroleptics. Age range 50 to 60 years At least two months have passed since their operation

Exclusion criteria

Exclusion criteria: Unstable angina Uncompensated heart failure Myocardial infarction over the past four weeks Ventricular arrhythmia

Design outcomes

Primary

Measure	Time frame
ABCB4 gene expression. Timepoint: 24 hours before the start of the protocol and 48 hours after the last training session. Method of measurement: ABCB4 gene expression and ELISA method.;APOA plasma levels,. Timepoint: 24 hours before the start of the protocol. Method of measurement: Gene expression and ELISA method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Rashid lamir

Islamic Azad University

Rashidlamir@um.ac.ir+98 51 3380 6000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026