Effect of treatment with (Hydrocortisone+ Ascorbic acid+ Neurobion)on multiple trauma patients

Evaluation of treatment with (Hydrocortisone+ Ascorbic acid+ Neurobion) on the prognosis of multiple trauma patients in comparison with control group

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201116049410N1

Enrollment

Registered

2021-07-14

Start date

2021-09-22

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

multiple trauma. Unspecified multiple injuries

Interventions

Intervention 1: Intervention group: Patients in this group receive 1.5 g of vitamin C every 6 hours for 4 days, hydrocortisone 50 mg every 6 hours for 7 days, neurobion two ampoules every 12 hours for

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patient (age = 18 years) Multiple trauma patients Injury Severity Score greater than 15

Exclusion criteria

Exclusion criteria: Pregnancy History of adrenal insufficiency Patients with history of Immunosuppression Corticosteroid therapy within the last six months G6PD patients Hhistory of oxalate nephropathy Oliguria or anuria Known allergy to vitamin C, hydrocortisone, neurobion

Design outcomes

Primary

Measure	Time frame
General condition of the patient. Timepoint: Every day. Method of measurement: SOFA score.;Duration of hospitalization in the intensive care unit. Timepoint: At the time of leaving the Border Special Cases section. Method of measurement: The time interval between entering and leaving the intensive care unit.;Ventilation time. Timepoint: One time, at the extubation time. Method of measurement: Calculate the number of days connected to the ventilator.;Prognosis of the disease. Timepoint: Time to leave the intensive care unit. Method of measurement: Determining the patient's recovery status or death.	—

Measure

Time frame

General condition of the patient. Timepoint: Every day. Method of measurement: SOFA score.;Duration of hospitalization in the intensive care unit. Timepoint: At the time of leaving the Border Special Cases section. Method of measurement: The time interval between entering and leaving the intensive care unit.;Ventilation time. Timepoint: One time, at the extubation time. Method of measurement: Calculate the number of days connected to the ventilator.;Prognosis of the disease. Timepoint: Time to leave the intensive care unit. Method of measurement: Determining the patient's recovery status or death.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Masoudpour

Esfahan University of Medical Sciences

arash1360@gmail.com36692174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026