Acute myocardial infarction. Acute myocardial infarction, unspecified
Conditions
Interventions
Intervention 1: Intervention group: once injection of adipose tissue stem cells. Intervention 2: Intervention group: twice injection of adipose tissue stem cells. Intervention 3: Control group: recei
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Ages20- 60 Years Genders: Both First MI within 3 to 5 days Post AMI LVEF less than 40% as assessed by echocardiography Negative pregnancy test ( in women with childbearing potential )
Exclusion criteria
Exclusion criteria: History of prior anterior myocardial infarction Patients with regional wall motion abnormalities in the non-infarct region prior CABG Patients with significant valve disease; defined as stenosis or regurgitation graded as greater than moderate (2+) Patients with another etiology of LV dysfunction (known/suspected non ischemic cardiomyopathy, previous anthracycline therapy, known ethanol abuse (greater than 6 oz. ethanol/day on a regular basis). Poor echocardiography window Active infection or history of recurrent infection or positive test for syphilis (RPR), hepatitis B and C (HBsAg, Anti-HCV), HIV and HTLV-1 Documental Terminal illness or malignancy Previous bone marrow transplant Autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ejection Fraction. Timepoint: within 6 months of intervention. Method of measurement: echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematologic variables, cardiac imaging (MRI), electrocardiogram. Timepoint: 2 weeks , 3 months , and 6 months after intervention. Method of measurement: lab kit for hematologic variables. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad monabati
Shiraz University of Medical Sciences
Outcome results
None listed