The effect of eradication of Helicobacter pylori infection in the treatment of rosacea

Evaluation of the treatment of rosacea patients after eradication of Helicobacter pylori infection and treatment with topical gel of metronidazole 75% in comparison with control.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201116049400N1

Enrollment

120

Registered

2021-07-30

Start date

2021-07-23

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rosacea. Rosacea

Interventions

Intervention 1: Intervention group: In addition to the standard treatment with Metro Nidazole 75% topical gel (Metromax produced by Tehran Shimi Company) (twice a day), in order to eradicate the infec

Eligibility

Sex/Gender

All

Age

17 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 17-56 Subjects with rosacea

Exclusion criteria

Exclusion criteria: Gastrointestinal symptoms (bloating, nausea, high intestinal upset, premature satiety, heartburn, ...) Age less than 17 and more than 65 years Antibiotics ( Bismuth subsalicylate) for the treatment of Helicobacter pylori eradication Use of proton pump inhibitors (Nexium and Prilosec) during the month before the start of the study Pregnancy or Breastfeeding

Design outcomes

Primary

Measure	Time frame
Determination of Immunoglobulin G (IgG) and Immunoglobulin M (IgM) levels of Helicobacter pylori and qualitative determination of Helicobacter pylori antigens. Timepoint: Measurement of IgG and IgM levels of Helicobacter pylori , evaluation of the presence of Helicobacter pylori antigen in the feces of patients and lesion size (before the intervention) and 2 months after the start of topical antibiotics and gels. Method of measurement: ELISA (Enzyme-Linked Immunosorbent Assay), EIA (Enzyme Immunoassay).	—

Measure

Time frame

Determination of Immunoglobulin G (IgG) and Immunoglobulin M (IgM) levels of Helicobacter pylori and qualitative determination of Helicobacter pylori antigens. Timepoint: Measurement of IgG and IgM levels of Helicobacter pylori , evaluation of the presence of Helicobacter pylori antigen in the feces of patients and lesion size (before the intervention) and 2 months after the start of topical antibiotics and gels. Method of measurement: ELISA (Enzyme-Linked Immunosorbent Assay), EIA (Enzyme Immunoassay).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Hossein Hejazi

Esfahan University of Medical Sciences

hejazi@med.mui.ac.ir+98 31 3792 9173

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026