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Comparison of the effect and side effects of intravenous epinephrine and ephedrine in controlling hypotension and heart rate in cesarean section women

Comparing the effect and complications of intravenous Epinephrine and Ephedrine in management of spinal anesthesia hypotension and bradycardia in elective caesarian section

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201115049395N1
Enrollment
126
Registered
2020-12-05
Start date
2020-09-14
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension and bradycardia following injection of spinal anesthesia.

Interventions

Intervention 1: Intervention group : Epinephrine is injected at a dose of 4 micrograms bolus until the mother reaches systolic blood pressure of more than 100 mm Hg. Intervention 2: control group :Int

Sponsors

Karaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Consent to participate in the study Pregnant women 40-20 years old in ASA2 class Gestational age 40-36 weeks A drop in blood pressure of more than 20% or a decrease in systolic blood pressure of less than 100 mm Hg

Exclusion criteria

Exclusion criteria: Contraindications for spinal anesthesia Primary blood pressure more than 90/140 mm Hg or heart disease Diagnosed diseases of the placenta Sensitivity to the drugs used

Design outcomes

Primary

MeasureTime frame
The rate of hypotension. Timepoint: Before injecting spinal anesthesia then every 2 minutes to 20 minutes and then every 5 minutes to 45 minutes. Method of measurement: Measurement by monitoring device.;Bradycardia. Timepoint: Before injecting spinal anesthesia then every 2 minutes to 20 minutes and then every 5 minutes to 45 minutes. Method of measurement: Measurement by monitoring device.

Secondary

MeasureTime frame
Apgar fetus. Timepoint: 1 minute and 5 minutes after delivery. Method of measurement: Apgar scoring form of 10 points.;Fetal pH. Timepoint: After delivery and umbilical cord incision. Method of measurement: By sending a cord blood sample to the laboratory and determining the pH of the fetus.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh moradi

Karaj University of Medical Sciences

fatiiiim73@gmail.com+98 21 3680 1995

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026