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The effect of combined training on ABCG4 gene expression and interleukin 4 and interleukin 10 factors in middle-aged men's blood mononuclear cells after coronary artery bypass graft

The effect of combined training on ABCG4 gene expression and interleukin 4 and interleukin 10 factors in middle-aged men's blood mononuclear cells after coronary artery bypass graft

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201115049393N1
Enrollment
26
Registered
2021-01-30
Start date
2017-08-24
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with coronary artery bypass grafting.

Interventions

Intervention 1: Control group: Intervention group: 8 weeks of cardiac rehabilitation (aerobic training and resistance training) including 3 sessions per week with an intensity of 80-50% of the reserve

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
50 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. No systolic blood pressure higher than 160 mm Hg and diastolic blood pressure higher than 100 mm Hg 2. Cognitive, visual and auditory health 3. Do not use neuroleptics 4. Do not use walking aids such as canes and walkers 5. At least 2 months have passed since their operation 6. Their functional capacity should not be less than five met. Each met represents a consumption of 3.5 ml of oxygen per kilogram of body weight per minute, which was estimated based on a modified Bruce test 7. Age range 50 to 65 years

Exclusion criteria

Exclusion criteria: Unstable angina, irreversible heart failure, myocardial infarction over the past four weeks, ventricular arrhythmias.

Design outcomes

Primary

MeasureTime frame
ABCG4 gene expression and plasma levels of interleukin 4 and interleukin 10. Timepoint: 24 hours before the start of the protocol and 48 hours after the last training session. Method of measurement: Real-time-PCT gene expression and ELISA method.

Secondary

MeasureTime frame
ABCG4 gene expression of interleukin 4 and interleukin 10. Timepoint: 24 hours before and 24 hours after the first and last training session. Method of measurement: Real-time-PCR method and ELISA method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Amir Rashid Lamir

Islamic Azad University

amir.rashidlamir@gmail.com+98 51 3880 4840

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026