The effect of injectable Acetaminophen and Magnesium Sulfate on pain after Maxillofacial surgery.

Comparison of the effect of Apotel and Magnesium Sulfate analgesics on pain and Pethidine dose after Maxillofacial surgery.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201113049375N1

Enrollment

Registered

2021-09-10

Start date

2021-09-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post surgical pain control in Maxillofacial surgery.

Interventions

Intervention 1: Intervention group 1: Patients receiving Apotel one gram, Acetaminophen 50 ml, Alborz daroo, One gram is injected to the patient one hour before the end of surgery. Intervention 2: In

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Men and Women 45 - 18 years American Society of Anesthesiologists (ASA) Class I and II anesthesia Patients have informed consent to study Candidate for Maxillofacial surgery No Maxillofacial reoperation or Emergency or Multiple trauma

Exclusion criteria

Exclusion criteria: Having any severe drug allergies . . . . . . Be addicted to drugs, alcohol and psychedelics Severe liver and kidney disease or severe anemia Serious heart rhythm disorder and severe arrhythmia Chronic treatment with corticosteroids or calcium channel blockers or NSAIDs

Design outcomes

Primary

Measure	Time frame
Pain rate in Apotel group. Timepoint: Measurement of pain after injection of Apotel in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Visual Analogue Scale questionnaire.;Pain rate in Magnesium Sulfate group. Timepoint: Measurement of pain after injection of Magnesium Sulfate in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Visual Analogue Scale questionnaire.;Need for use of opioid in the Apotel group. Timepoint: Measurement of the need for opioid use after Apotel injection in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Depending on the patient's needs for 30 mg of Pethidine at a time.;Need for use of opioids in the group of Magnesium Sulfate. Timepoint: Measurement of the need for opioid use after magnesium sulfate injection in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Depending on the patient's needs for 30 mg of Pethidine at a time.	—

Measure

Time frame

Pain rate in Apotel group. Timepoint: Measurement of pain after injection of Apotel in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Visual Analogue Scale questionnaire.;Pain rate in Magnesium Sulfate group. Timepoint: Measurement of pain after injection of Magnesium Sulfate in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Visual Analogue Scale questionnaire.;Need for use of opioid in the Apotel group. Timepoint: Measurement of the need for opioid use after Apotel injection in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Depending on the patient's needs for 30 mg of Pethidine at a time.;Need for use of opioids in the group of Magnesium Sulfate. Timepoint: Measurement of the need for opioid use after magnesium sulfate injection in patients with Maxillofacial surgery in recovery, 4, 8 and 12 hours after recovery. Method of measurement: Depending on the patient's needs for 30 mg of Pethidine at a time.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Khalili

Islamic Azad University

khalilimahdi67@gmail.com+98 21 2268 6549

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026