Comparison of anticandidal efficacy of Silver Diamine Fluoride and Chlorhexidine in children with severe early childhood caries

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201104049255N1

Enrollment

Registered

2021-05-08

Start date

2021-06-04

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe early childhood caries. Dental caries, unspecified

Interventions

Intervention 1: Intervention group: Single topical treatment with 38% Silver Diamine Fluoride solution (Fagamin , Tedequim Argentina). Intervention 2: Control group: Single topical treatment with 1%

Eligibility

Sex/Gender

All

Age

No minimum to 5 Years

Inclusion criteria

Inclusion criteria: Children younger than 5 years old Children with severe early childhood caries (according to defs scale) Healthy children with no systemic condition Children with positive Candida albicans culture of dental plaque

Exclusion criteria

Exclusion criteria: Children who underwent either antibiotic, antifungal or fluoride therapy (systemic or topical) within the last 1 month prior to the study children with orthodontic or prosthodontic appliances special health care needs children children with no written informed consent granted

Design outcomes

Primary

Measure	Time frame
Dental plaque Candida albicans colony count 2 and 30 days after treatment. Timepoint: Dental plaque colony count of Candida at beginning of the study (before the intervention) and 2 and 30 days after treatment with Silver Diamine Fluoride or Chlorhexidine. Method of measurement: candida colony count.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Yazdizadeh

Babol University of Medical Sciences

Mn.yazdizadeh@gmail.com+98 11 3229 1408

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026