effect of valsartan / amlodipine on LVDD

Comparison of the effect of single-pill combination of valsartan / amlodipine with valsartan alone on left ventricular diastolic dysfunction(LVDD) in patients with hypertension(HTN)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201102049232N1

Enrollment

122

Registered

2021-01-01

Start date

2020-12-21

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: hypertension. Condition 2: Left ventricular diastolic dysfunction. Essential (primary) hypertension Diastolic (congestive) heart failure

Interventions

Intervention 1: Intervention group: There is a group that receive Abaidi's single pill Valsartan / Amlodipine 80/5 for one month and if the blood pressure is not controlled, the dose will increase to1

Eligibility

Sex/Gender

All

Age

No minimum to 70 Years

Inclusion criteria

Inclusion criteria: All patients with newly diagnosed hypertension Patients with hypertension with evidence of echocardiographic LVDD

Exclusion criteria

Exclusion criteria: Taking ARB or ACEI drugs in the last three months Left Ventricular Ejection Fraction less than 50% Major valvular heart disease Previous allergy or contraindication to the use of the studied drugs Serum creatinine above 1.5 Lack of blood pressure control with the studied drugs Patient dissatisfaction with continuing the study

Design outcomes

Primary

Measure	Time frame
Left ventricular diastolic dysfunction. Timepoint: At the beginning of the study and 6 months after starting medication for hypertension. Method of measurement: Trans thoracic echocardiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Pazoki

Qazvin University of Medical Sciences

a.pazoki@qums.ac.ir+98 28 3332 6034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026