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Addition of clinidine to articaine solution in pain relief after root canal treatment

The Addition of Clonidine to the Articaine/Epinephrine for Inferior Alveolar Nerve Block Reduces Postoperative Pain of Patients with Irreversible Pulpitis: A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201031049199N1
Enrollment
100
Registered
2020-11-17
Start date
2017-10-12
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative pain. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: The clonidine group (Articaine + Epinephrine + Clonidine, n = 50) received an IANB with 0.2 ml clonidine (Catapressan amp., 150 µg/ml
BoehringerIngelheim, Ingelheim am Rhein, Germany) in addition to 1.8 ml of 4% articaine (Daropakhsh, Tehran, Iran) with 1:100,000 epinephrine. Intervention 2: Control group: The control group (Articai

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Aged 15-60 ASA grade I Have symptomatic irreversible pulpitis in a mandibular posterior tooth

Exclusion criteria

Exclusion criteria: necessity for multi-visit treatments consumption of analgesics or opioids in a week periodontal problems underlying diseases such as diabetes, hypertension or other cardiovascular diseases an allergy or contraindication to clonidine, articaine, or epinephrine active signs of oral infection or inflammation Pregnant or lactating mothers drug abusers, and patients taking a ß-blocker

Design outcomes

Primary

MeasureTime frame
Pain score. Timepoint: 12 h after- 24 h after-36 h after- 48 h after-72 h after procedure. Method of measurement: Heft- parker visual analog scale.

Secondary

MeasureTime frame
Heart rate. Timepoint: Immediately Before administration- 5 minutes after administration. Method of measurement: digital blood pressure monitor (M3, Omron, omron healthcare co MTD, japan).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Elham Shadmehr

Esfahan University of Medical Sciences

elham.shadmer@gmail.com+98 31 3440 8524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026