Polycystic Ovarian Syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: Astaxanthin consumption. In this group, patients take 12 mg of astaxanthin daily ( in 2 capsules of 6mg twice in the morning and at night) for 60 days. Their routin
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Hyperandrogenism Oligo/anovulation (ovulationabnormality) Polycystic ovaries on ultrasound
Exclusion criteria
Exclusion criteria: Pregnancy Adrenal hyperplasia Androgen-secretingtumors Hyperprolactinemia Thyroid dysfunction Diabetes mellitus or glucose tolerance Male infertility factors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ER stress and apoptotic factor. Timepoint: 60 days after the beginning of the intervention. Method of measurement: real time pcr, western blot.;High density lipoprotein cholesterol (HDL). Timepoint: Before and 60 days after the intervention. Method of measurement: Enzyme kit.;Glutathione peroxidase 3 (GPX3) gene. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Real time pcr.;Pentraxin 3 (PTX3) gene. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Real time pcr.;Runt-related transcription factor 2 (RUNX2) gene. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Real time pcr.;Phosphoglycerate kinase 1 (PGK1) gene. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Real time pcr.;Regulator of G-protein signaling2(RGS2)gene. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Real time pcr. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number and quality of oocytes. Timepoint: 60 days after the beginning of the intervention. Method of measurement: Counting,light microscope.;Number and quality of embryos. Timepoint: 60-63 days after the beginning of the intervention. Method of measurement: Counting,light microscope.;Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: beta-hCG blood test.;Fasting insulin. Timepoint: Before and 60 days after the intervention. Method of measurement: Elisa kit.;Total cholesterol. Timepoint: Before and 60 days after the intervention. Method of measurement: Enzyme kit.;Triglycerides. Timepoint: Before and 60 days after the intervention. Method of measurement: Enzyme kit.;Low density lipoprotein (LDL). Timepoint: Before and 60 days after the intervention. Method of measurement: Enzyme kit.;Fasting blood sugar. Timepoint: Before and 60 days after the intervention. Method of measurement: Enzyme kit.;Malondialdehyde (MDA). Timepoint: Before and 60 days after the intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity (TAC). Timepoint: Before and 60 days after the intervention. Method of measurement: Spectrophotometry.;Superoxide dismutase (SOD). Timepoint: Before and 60 days after the intervention. Method of measurement: Spectrophotometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTehran University of Medical Sciences
Tehran University of Medical Sciences
Outcome results
None listed