Major depressive disorder. Major depressive disorder, single episode
Conditions
Interventions
Intervention 1: Intervention group: This group receives 200 mg of modafinil (2 of 100 mg tablets made in Iran) every morning and will be re-evaluated by Hamilton Depression Inventory three weeks and
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 to 65 years Diagnosis of clinical Major Depressive Disorder based on the DSM5 criteria A score above 25 on the Hamilton Depression Rating Scale Written consent to enter the study from the patient or her /his guardian The patient is able to take medicine
Exclusion criteria
Exclusion criteria: Depression caused by physical illness or the use of drugs and substances Existence of any severe and chronic physical illness (brain, cardiovascular disease, seizure or history of substance abuse) History of gastric ulcer Pregnancy History of alcohol use and substance abuse during the 6 months prior to the start of the project History of manic episodes Intellectual disorders Psychosis Breastfeeding High severity of depression such as melancholic and suicidal ideation History of receiving antidepressant in two to four weeks before starting the drug (eg MAOIs in the last four weeks but SSRIs or mirtazapine or SNRIs in the last two weeks) History of non-response or shifting with the studied drugs History of receiving lithium, lamotrigine, sodium valproate, atypical antipsychotics available other than ziprasidone and aripiprazole, in the past two weeks or one month (depending on the half-life of the drug or based on similar studies) Being treated with Ritalin for any reason Existence of mixed symptoms in the recent episode Existence of anxiety disorder, especially panic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score on the Hamilton questionnaire. Timepoint: At the beginning of the study and three weeks and six weeks after the start of the intervention. Method of measurement: The Hamilton questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGolsa Safaei
Ahvaz University of Medical Sciences
Outcome results
None listed