midodrine effectiveness in patients who have low mean atrial pressure after open heart surgery

randomized clinical trial of midodrine effectiveness in patients who underwent open heart surgery and after surgery their mean atrial blood pressure is low despite receiving at least 24 hours intravenous inotrope in Tehran Heart Center in 1399 to 1400

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201025049139N1

Enrollment

100

Registered

2021-01-15

Start date

2020-10-31

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CABG. Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasm

Interventions

Intervention 1: Intervention group: we prescribe midodrine 5 mg every 12 hours, after IV inotrope discontinuation we change the dose to 2.5 mg every 12 hours an after 3 days discontinue midodrine. Int

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: More than 18 years old Admitted in ICU Systolic blood pressure less than 90 mmHg or mean atrial pressure less than 80 mmHg Dependent to IV vassopressor Received at least 24 hours IV vassopressor and can not discontinue it Operation type is CABG

Exclusion criteria

Exclusion criteria: hypovolemia septic shock kidney failure (Cr>2mg/dl) hepatic failure electrolyte disturbance pregnancy tamponed active bleeding hypothyroid hyperthyroid midodrine allergy

Design outcomes

Primary

Measure	Time frame
Blood pressure dependency rate to IV inotrope after midodrine initiation. Timepoint: study entrance time and 48 hours after that. Method of measurement: with Sphygmomanometer.;Intravenous vasopressor dose. Timepoint: after intravenous vasopressor discontinuation. Method of measurement: microgram.;ICU length of stay. Timepoint: after patient discharge from ICU. Method of measurement: according to hour.;Hospital length of stay. Timepoint: after patient discharge. Method of measurement: according to hour.;Left ventricular function. Timepoint: at the time of randomization. Method of measurement: echocardiography.;Creatinine. Timepoint: at the time of randomization. Method of measurement: in lab.	—

Measure

Time frame

Blood pressure dependency rate to IV inotrope after midodrine initiation. Timepoint: study entrance time and 48 hours after that. Method of measurement: with Sphygmomanometer.;Intravenous vasopressor dose. Timepoint: after intravenous vasopressor discontinuation. Method of measurement: microgram.;ICU length of stay. Timepoint: after patient discharge from ICU. Method of measurement: according to hour.;Hospital length of stay. Timepoint: after patient discharge. Method of measurement: according to hour.;Left ventricular function. Timepoint: at the time of randomization. Method of measurement: echocardiography.;Creatinine. Timepoint: at the time of randomization. Method of measurement: in lab.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Ziaoddini

Tehran University of Medical Sciences

mostafa_zia@yahoo.com+98 34 3212 1088

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026