Comparison of two methods of dose calculating of propofol for induction of general anesthesia according to either Ideal Body Weight(IBW) or Fat Free Mass(FFM), in morbid obese patient: parallel double - blinded clinical trial

Comparison of two methods of calculating the dose of propofol for induction of general anesthesia according to either Ideal Body Weight(IBW) or Fat Free Mass(FFM), in morbid obese patient: parallel double - blinded clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201024049135N1

Enrollment

Registered

2021-02-06

Start date

2021-02-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbid obese. Overweight and obesity

Interventions

Intervention 1: Intervention group1: Propofol 1% (B.Braun Melsungen AG,34209 Melsungen, Germany) administration with the dose of 2 milligram per kilogram according to ideal body weight(IBW). Interven

Eligibility

Sex/Gender

All

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: Obesity BMI more than 35 Age 18-59 years ASA ll and lll Undergoing for bariatric surgery

Exclusion criteria

Exclusion criteria: Difficult airway The need for awake intubation Severe systemic diseases Impaired renal and hepatic function History of allergies to the drugs studied Behavioral disorders and the use of psychiatric drugs

Design outcomes

Primary

Measure	Time frame
Onset time of the dose of propofol (electroencephalographic depression) according to the study group which is determined by a decrease in bispectral index to less than 60. Timepoint: During induction of general anesthesia. Method of measurement: evaluated by bispectral index recording.	—

Secondary

Measure	Time frame
Evaluation of the extent of decrease in mean arterial pressure. Timepoint: During induction of anesthesia and every 3 minutes. Method of measurement: Through noninvasive blood pressure monitoring.;Measure the maximum depth of anesthesia. Timepoint: During induction of anesthesia and every 3 minutes. Method of measurement: Bispectral index Monitoring.;Evaluation of the extent of heat rate decrease during induction of anesthesia. Timepoint: Continuous monitoring. Method of measurement: Electrocardiography.	—

Measure

Time frame

Evaluation of the extent of decrease in mean arterial pressure. Timepoint: During induction of anesthesia and every 3 minutes. Method of measurement: Through noninvasive blood pressure monitoring.;Measure the maximum depth of anesthesia. Timepoint: During induction of anesthesia and every 3 minutes. Method of measurement: Bispectral index Monitoring.;Evaluation of the extent of heat rate decrease during induction of anesthesia. Timepoint: Continuous monitoring. Method of measurement: Electrocardiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoudabeh ???Djalali Motlagh

Iran University of Medical Sciences

djalalimotlagh.s@iums.ac.ir+98 21 8214 1600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026