Evaluation of the efficacy of Silymarin in patients with COVID-19

Evaluation of the efficacy of Silymarin nanomicelles in hospitalized patients with COVID-19

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201024049130N1

Enrollment

Registered

2021-06-21

Start date

2021-05-31

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with COVID-2019. COVID-19

Interventions

Intervention 1: Intervention group: patients with COVID-19 in addition to a standard regimen(Includes dexamethasone and remdesivir and in case of suspected bacterial superinfection with parental antib

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with clinical or laboratory diagnosis of covid-19 should be hospitalized based on the opinion of a specialist physician. age between 18 to 75 Signing an informed consent form

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Active liver disease Severe renal failure GFR <30 ml/min Inability of the patient to swallow oral medication

Design outcomes

Primary

Measure	Time frame
Time to clinical improvement. Timepoint: 28 days from study enrollment. Method of measurement: Instrument name: Ordinal Scale for Clinical Improvement. The Sequential Clinical Recovery Scale is used by the World Health Organization for Covid patients. This scale contains 8 scores. the scores include: 1. Not hospitalized, no limitations on activities 2. Not hospitalized, limitation on activities 3. Hospitalized, not requiring supplemental oxygen 4. Hospitalized, requiring supplemental oxygen by mask or nasal prongs 5. Hospitalized, on non-invasive ventilation or high flow oxygen devices 6. Hospitalized, on invasive mechanical ventilation 7. Hospitalized, on invasive mechanical ventilation + additional organ support (pressors, RRT, ECMO) 8. Death.	—

Measure

Time frame

Time to clinical improvement. Timepoint: 28 days from study enrollment. Method of measurement: Instrument name: Ordinal Scale for Clinical Improvement. The Sequential Clinical Recovery Scale is used by the World Health Organization for Covid patients. This scale contains 8 scores. the scores include: 1. Not hospitalized, no limitations on activities 2. Not hospitalized, limitation on activities 3. Hospitalized, not requiring supplemental oxygen 4. Hospitalized, requiring supplemental oxygen by mask or nasal prongs 5. Hospitalized, on non-invasive ventilation or high flow oxygen devices 6. Hospitalized, on invasive mechanical ventilation 7. Hospitalized, on invasive mechanical ventilation + additional organ support (pressors, RRT, ECMO) 8. Death.

—

Secondary

Measure	Time frame
Mortality. Timepoint: 28 days from study enrollment. Method of measurement: All cause mortality (ACM).;Length of Hospitalization. Timepoint: Hospitalization time at the discretion of the physician. Method of measurement: days.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Aryan

Artesh University of Medical Sciences

h.aryanmd@gmail.com+98 21 8609 4475

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026