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Comparison of two freezed emberyo transfer cycle in PCOS patients ; pretreatment with duphaston and GNRH agonist versus duphaston without GNRH agonist

Comparison of two freezed emberyo transfer cycle in PCOS patients ; pretreatment with duphaston and GNRH agonist versus duphaston without GNRH agonist; A non inferiority open lable clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201024049128N4
Enrollment
284
Registered
2022-11-23
Start date
2022-09-06
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: pre-treatment with duphaston: in these patients, along with the routine protocol of frozen embryo transfer, duphaston 10 mg daily is prescribed from the 15th to the
leuprorelin acetate, Iran) on the 21st day of the previous menstrual cycle It will be injected subcutaneously, from the 15th to the 25th day of the cycle, Duphaston 10 mg is prescribed daily.

Sponsors

Avicenna Infertility Clinic
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 39 Years

Inclusion criteria

Inclusion criteria: Having PCOS according to the Rotterdam criteria (oligomenorrhea, hyperandrogenism or hyperandrogenemia and polycystic ovary) The age of the lady is more than 20 years 5-day embryo freezing The natural cavity of the uterus Intracytoplasmic sperm injection (ICSI) cycle

Exclusion criteria

Exclusion criteria: The age of the lady is more than 39 years Having a history of endometriosis Having moderate or severe adenomyosis FSH= 12 mIU/mL Surrogate mothers A history of more than 3 previous failed embryo transfers Sex selection cycles Donation cycles Visibility of hydrosalpinx in ultrasound The presence of any type of uterine abnormalities Presence of submucosal myoma larger than 2 cm Having Asherman syndrome

Design outcomes

Primary

MeasureTime frame
The main outcome under study is the rate of clinical fertility in two treatment groups. Timepoint: ß-hCG serum level is measured on days 14 and 16 after embryo transfer. Method of measurement: Serum ß-hCG level using blood test.

Secondary

MeasureTime frame
Endometrial thickness. Timepoint: The tenth day of the menstrual cycle. Method of measurement: sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Bita Badehnoosh

Avicenna Infertility Clinic

b_badehnoosh@yahoo.com1941913114

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026