Effect of Antibiotics in superficial and deep infection after cholecystectomy

Evaluation of the effect of antibiotics after surgery in patients with mild to moderate cholecystitis on the rate of infection at the site of surgery and deep infection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201023049120N1

Enrollment

Registered

2021-04-01

Start date

2019-03-21

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystitis. Acute cholecystitis

Interventions

Intervention 1: Intervention group: Patients in the intervention group (postoperative antibiotic therapy) are treated with oral antibiotics with ciprofloxacin 500 mg every 12 hours and metronidazole 2

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who are classified as mild or moderate cholecystitis according to the Tokyo 2018 guideline Referred to the emergency department of Sina and Amir Alam hospitals from the March 21th, 2019 to March 20th, 2021 Age over 18 years

Exclusion criteria

Exclusion criteria: Patients with Severe cholecystitis (grade III) Patients who have had abdominal pain for more than 5 days Patients who have been diagnosed with common bile duct stones during preoperative or postoperative examinations Patients diagnosed with cholangitis include patients with concomitant pancreatitis Cirrhotic patients Patients with hepatobiliary system cancers Patients with acquired or primary immunodeficiency Patients with antibiotic susceptibility to beta-lactams Patients with cholecystitis since diagnosis acute mild or moderate for them until surgery more than 48 interruptions Pregnant or lactating patients Patients who did not consent to participate in this study

Design outcomes

Primary

Measure	Time frame
The rate of infection at the operation site. Timepoint: Up to 30 days after surgery(At the time of hospitalization daily and every two weeks thereafter). Method of measurement: Presence of purulent discharge from the wound, positive culture of wound discharge sampled by sterile method with one or more of the following symptoms: pain, tenderness, local swelling, warmth or redness of the wound. The diagnosis of SSI is made by the patient's professor or resident.;The rate of deep infection. Timepoint: Up to 30 days after surgery (At the time of hospitalization daily and every two weeks thereafter). Method of measurement: Presence of purulent discharge from the wound, positive culture of wound discharge sampled by sterile method with one or more of the following symptoms: pain, tenderness, local swelling, warmth or redness of the wound. The diagnosis of SSI is made by the patient's professor or resident.	—

Measure

Time frame

The rate of infection at the operation site. Timepoint: Up to 30 days after surgery(At the time of hospitalization daily and every two weeks thereafter). Method of measurement: Presence of purulent discharge from the wound, positive culture of wound discharge sampled by sterile method with one or more of the following symptoms: pain, tenderness, local swelling, warmth or redness of the wound. The diagnosis of SSI is made by the patient's professor or resident.;The rate of deep infection. Timepoint: Up to 30 days after surgery (At the time of hospitalization daily and every two weeks thereafter). Method of measurement: Presence of purulent discharge from the wound, positive culture of wound discharge sampled by sterile method with one or more of the following symptoms: pain, tenderness, local swelling, warmth or redness of the wound. The diagnosis of SSI is made by the patient's professor or resident.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Zabihi Mahmoudabadi

Tehran University of Medical Sciences

h.zabihi.dr@gmail.com+98 21 6312 1220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026