Evaluate of effect probiotic on treatment of systemic lupus erythematosus

Evaluate the effect of probiotics on the improvement of autoimmune inflammation in patients with systemic lupus erythematosus

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201019049073N1

Enrollment

Registered

2021-01-08

Start date

2020-10-28

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SLE( Systemic lupus erythematosus ). kinds of autoimmune diseases

Interventions

Intervention 1: Intervention group: In addition to common therapies, one oral probiotic FamiLact 2plus daily includes the strains of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamn

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: All patients with SLE have a SLEDAI score of 4.5 to 10. Patients should be between 18 and 45 years old. Patients are willing to cooperate in the project.

Exclusion criteria

Exclusion criteria: Patients will be excluded from the study if there is a change in the dose or number of medications taken by patients.

Design outcomes

Primary

Measure	Time frame
IL17, Evaluation of FOXP3, T-bet, GATA-3 and ROR ?t transcription factor gene expression by SYBR Green real-time RT-PCR method. Timepoint: Before intervention, 4 months after intervention. Method of measurement: Elisa test, SYBR Green real-time RT-PCR.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArezoo Faridzadeh

Mashhad University of Medical Sciences

Faridzadeha961@mums.ac.ir+98 51 3800 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026